The rise of 3D printing has changed the manufacturing industry. Now, the medical community is learning how to use this technology to create new therapies for diseases including cancer. Researchers at Georgia Tech have developed a new 3D printing tool that tells the separation of cancer cells from billions of blood cells in the body.
The 3D printed cell trap filters red blood cells and captures white blood cells and tumor cells. The isolated damaged portion is then used to diagnose cancer. The researchers say the tool can help understand cancer development and provide early warning of recurrence. They added that because doctors can directly study the circulating tumor cells in the patient's blood, it may also help to create personalized cancer treatments.
“With this device, we can handle clinically relevant blood volumes by capturing almost all white blood cells and filtering out red blood cells by size,” said A. Fatih Sarioglu, assistant professor of electrical and electronics at the Georgia Institute of Technology. “This leaves us with undamaged tumor cells that can be sequenced to determine the specific cancer type and unique characteristics of each patient's tumor.” Sarioglu used to have difficulty separating tumor cells from blood samples because cancer cells usually Will be mixed with billions of normal red blood cells and white blood cells. 3D printed cell traps provide a fast and low-cost way to identify damaged cells.
Previous methods of capturing circulating tumor cells require the use of microfluidic techniques to extract them from the blood. This technique uses specific markers on the cells. However, cancer cells change over time, making it difficult to accurately identify malignant cells.
Sarioglu and colleagues tested 3D printed cell traps with healthy human blood samples. The researchers added cancer cells to the laboratory samples. The results, published in the "Chip Lab", indicate that the well can separate 90% of tumor cells from blood cells. The experiment involves cells from prostate, breast and ovarian cancer, Sarioglu said, and the tool can capture tumor cells from any type of cancer.
The researchers said: "We hope this is indeed an enabling tool for clinicians." "In our lab, the mindset is always made by making the device simple enough to be used in hospitals, clinics and other Used in facilities that diagnose patients' diseases to simplify our research.